UBE2G1

UBE2G1 (Ubiquitin-conjugating Enzyme E2 G1): UBE2G1 is a member of the ubiquitin-conjugating enzyme family, playing a pivotal role in the ubiquitin-proteasome system, a fundamental cellular pathway responsible for protein degradation and turnover. Specifically, UBE2G1 functions in the conjugation of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. This enzymatic process is crucial for regulating various cellular functions, including cell cycle progression, DNA repair, and signal transduction. UBE2G1's activity is tightly regulated and orchestrated in concert with other components of the ubiquitin-proteasome system to ensure proper protein homeostasis and cellular function. Dysregulation of UBE2G1 has been implicated in various human diseases, including cancer, neurodegenerative disorders, and autoimmune diseases, underscoring its importance as a potential therapeutic target. Understanding the molecular mechanisms governing UBE2G1-mediated ubiquitination holds promise for developing novel strategies for the treatment of diseases associated with aberrant protein degradation pathways.