TOMM40

TOMM40 (Translocase of Outer Mitochondrial Membrane 40): TOMM40 is a key protein involved in mitochondrial biology, specifically in the process of protein import into the mitochondria. As a component of the TOM complex, TOMM40 facilitates the translocation of nuclear-encoded proteins across the outer mitochondrial membrane, where they can fulfill various essential functions within the mitochondria. This protein is particularly notable for its association with Alzheimer's disease, as certain variants of TOMM40 have been implicated in modulating the risk and age of onset of the disease. Beyond Alzheimer's, TOMM40 has been implicated in other neurodegenerative disorders and age-related cognitive decline, underscoring its significance in mitochondrial dysfunction and neuronal health. Understanding the role of TOMM40 in mitochondrial protein import and its implications in neurodegenerative diseases holds promise for developing targeted therapies and diagnostic strategies aimed at mitigating mitochondrial dysfunction and associated pathologies.