TGM2

TGM2 (Transglutaminase 2): Transglutaminase 2, a multifunctional enzyme, plays a pivotal role in post-translational modification of proteins through its ability to catalyze the cross-linking of glutamine and lysine residues. This enzyme is involved in a diverse range of cellular processes, including apoptosis, cell differentiation, and tissue repair, by facilitating the stabilization and restructuring of the extracellular matrix. TGM2's activity is crucial in the pathophysiology of several diseases, such as neurodegenerative disorders, fibrotic diseases, and certain forms of cancer, where its dysregulation contributes to disease progression. The enzyme's involvement in the immune response, particularly in the context of celiac disease, where it deamidates gluten peptides leading to an autoimmune response, underscores its significance in both health and disease. Given its wide-ranging roles in cellular function and disease mechanisms, TGM2 represents a potential therapeutic target for addressing disorders associated with its aberrant activity.