SOAT2

SOAT2 (Sterol O-Acyltransferase 2): SOAT2, a member of the sterol O-acyltransferase family, is a crucial enzyme involved in lipid metabolism, particularly in the esterification of cholesterol. This enzyme plays a significant role in the regulation of cellular cholesterol levels by converting free cholesterol into cholesterol esters, which are stored in lipid droplets or incorporated into lipoproteins for transportation. SOAT2 is primarily expressed in tissues involved in lipid metabolism, such as the liver, intestine, and macrophages. Its activity is tightly regulated and responsive to cellular cholesterol levels, serving as a key mechanism to prevent cholesterol toxicity and maintain lipid homeostasis. Dysregulation of SOAT2 activity has been implicated in various metabolic disorders, including atherosclerosis, obesity, and non-alcoholic fatty liver disease (NAFLD). Therefore, SOAT2 represents a potential therapeutic target for modulating cholesterol metabolism and mitigating the risk of cardiovascular and metabolic diseases. Understanding the intricate regulation and function of SOAT2 offers insights into lipid metabolism and provides avenues for the development of novel therapeutic interventions targeting dyslipidemia and related disorders.