SLC4A4

SLC4A4 (Solute Carrier Family 4, Member 4): SLC4A4, part of the solute carrier family, is predominantly involved in the regulation of bicarbonate transport and acid-base balance within the body. It functions as an electrogenic sodium bicarbonate cotransporter, primarily expressed in the kidneys and pancreas, playing a critical role in renal bicarbonate reabsorption and pH regulation. Through its action, SLC4A4 facilitates the fine-tuning of bicarbonate secretion and reabsorption processes, essential for maintaining the body's overall acid-base homeostasis. Mutations in the SLC4A4 gene are associated with various renal tubular acidosis disorders, characterized by an inability to properly acidify the urine, leading to systemic acidosis. This highlights the importance of SLC4A4 in renal function and its potential as a therapeutic target in treating disorders related to electrolyte imbalance and acid-base dysregulation.