SERPINB1

SERPINB1 (Serpin Family B Member 1): SERPINB1, a member of the serpin (serine protease inhibitor) family, plays a crucial role in regulating proteolytic pathways involved in inflammation and immune responses. It primarily inhibits neutrophil elastase and cathepsin G, enzymes released by neutrophils during inflammation, preventing excessive tissue damage. SERPINB1's protective role in maintaining lung tissue integrity is highlighted in conditions like cystic fibrosis and chronic obstructive pulmonary disease (COPD), where its deficiency or dysregulation can lead to enhanced tissue degradation and disease progression. Its function in controlling protease activity underscores its importance in balancing the body's need to fight infection with the need to protect tissue from inflammation-induced damage.