RPA2

RPA2 (Replication Protein A2): RPA2, a subunit of the Replication Protein A (RPA) complex, serves as a crucial player in DNA replication, repair, and recombination processes within the cell. As part of the RPA complex, RPA2 functions in the stabilization and protection of single-stranded DNA (ssDNA) intermediates, facilitating the progression of DNA replication forks and safeguarding genomic integrity. By binding to exposed ssDNA regions, RPA2 prevents their degradation and promotes the recruitment of other DNA repair proteins, thereby orchestrating efficient DNA damage response pathways. Moreover, RPA2 participates in various cellular processes beyond DNA replication, including telomere maintenance, DNA damage checkpoint activation, and transcriptional regulation. Dysregulation or mutations in RPA2 can lead to genomic instability, predisposing cells to cancer development and other genetic disorders. Understanding the intricate roles of RPA2 in maintaining genome stability provides valuable insights into the mechanisms underlying DNA metabolism and offers potential avenues for targeted therapeutic interventions in diseases associated with DNA repair deficiencies.