RNF220

RNF220 (Ring Finger Protein 220): RNF220 is a member of the ring finger protein family, characterized by its ring finger domain, which is implicated in mediating protein-protein interactions and ubiquitination processes. This enzyme plays a significant role in the ubiquitin-proteasome system, a critical pathway for protein degradation and turnover, which is essential for maintaining cellular homeostasis. Through its E3 ubiquitin ligase activity, RNF220 is involved in targeting specific substrates for degradation, thus regulating various cellular processes including signal transduction, transcriptional control, and the cell cycle. The dysregulation of RNF220 activity can contribute to pathological conditions, such as cancer, neurodegenerative diseases, and immune disorders, by affecting the stability and function of key regulatory proteins. Understanding the specific roles and mechanisms of RNF220 in ubiquitination highlights its potential as a therapeutic target in diseases associated with protein misfolding and degradation pathways.