RHOBTB2

RHOBTB2 (Rho-related BTB domain-containing protein 2): RHOBTB2 is a member of the Rho family of small GTPases, known for their roles in regulating various cellular processes including cytoskeletal dynamics, cell migration, and cell cycle progression. Unlike traditional Rho GTPases, RHOBTB2 possesses an additional BTB (Bric-a-brac, Tramtrack, and Broad complex) domain, suggesting its involvement in protein-protein interactions and potential regulatory functions beyond classical Rho signaling pathways. RHOBTB2 has been implicated in diverse cellular processes, including cell proliferation, apoptosis, and intracellular trafficking. It also plays a role in maintaining mitochondrial dynamics and function, as well as modulating cellular responses to oxidative stress. Dysregulation of RHOBTB2 has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases, underscoring its importance in cellular homeostasis and disease pathogenesis. The multifaceted functions of RHOBTB2 highlight its potential as a therapeutic target for diseases characterized by aberrant cellular processes. Understanding the intricate mechanisms by which RHOBTB2 regulates cellular physiology may pave the way for the development of novel therapeutic interventions aimed at modulating its activity in disease contexts.