MTHFD2

MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2): MTHFD2 is an enzyme that plays a vital role in the mitochondrial one-carbon metabolic pathway, crucial for nucleotide biosynthesis, methylation reactions, and amino acid homeostasis. This enzyme is highly expressed in rapidly dividing cells, including cancer cells, where it contributes to the synthesis of purines and thymidylate, essential for DNA replication and repair. MTHFD2's involvement in cellular metabolism and proliferation highlights its importance in developmental processes and cellular growth. Due to its pivotal role in supporting the metabolic demands of tumor growth and its limited expression in normal adult tissues, MTHFD2 has emerged as a potential target for cancer therapy. Its inhibition could disrupt the metabolic flexibility of cancer cells, making it a focus of interest for the development of novel anticancer strategies. The study of MTHFD2's function and regulation offers insights into metabolic adaptations in cancer and the potential for therapeutic interventions targeting metabolic pathways.