MFF

MFF (Mitochondrial Fission Factor): MFF plays a crucial role in mitochondrial dynamics, particularly in the process of mitochondrial fission, which is essential for mitochondrial distribution, quality control, and energy metabolism. By recruiting dynamin-related protein 1 (Drp1) to the mitochondrial outer membrane, MFF facilitates the division of mitochondria, a process vital for cell health, growth, and response to metabolic demands. Mitochondrial fission, mediated by MFF, is critical for mitochondrial turnover and the removal of damaged mitochondria, thereby contributing to cellular energy homeostasis and the prevention of apoptosis. Dysregulation of MFF function can lead to abnormal mitochondrial morphology and has been implicated in a variety of pathological conditions, including neurodegenerative diseases, cardiovascular diseases, and metabolic syndromes. The modulation of mitochondrial fission through MFF presents a potential therapeutic target for diseases associated with mitochondrial dysfunction, emphasizing the importance of MFF in cellular and organismal health.