MAP3K10

MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10): MAP3K10, also known as MLK2 (Mixed Lineage Kinase 2), is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, which plays a pivotal role in signaling pathways that regulate cell proliferation, differentiation, and apoptosis. This kinase acts as an upstream activator of the MAP kinase (MAPK) signaling cascade, responding to extracellular signals and translating them into cellular responses. MAP3K10's involvement is crucial for the development and maintenance of various physiological processes, and its activity is linked to neuronal function, immune responses, and stress responses. Dysregulation of MAP3K10 has been implicated in several pathological conditions, including neurodegenerative diseases, inflammatory disorders, and cancer, highlighting its significance in both normal cellular functions and disease states. The precise modulation of MAP3K10 activity underscores its potential as a therapeutic target for treating diseases associated with aberrant MAPK signaling.