INPPL1

INPPL1 (Inositol Polyphosphate Phosphatase-Like 1): INPPL1, also known as SHIP2 (Src Homology 2 domain-containing Inositol Phosphatase 2), is a phosphatase that plays a crucial role in the regulation of phosphoinositide signaling pathways, which are integral to various cellular processes such as proliferation, survival, and migration. This enzyme specifically dephosphorylates the 5' position of the inositol ring in phosphatidylinositol 3,4,5-trisphosphate (PIP3), thereby acting as a negative regulator of the PI3K (phosphoinositide 3-kinase) signaling pathway. INPPL1's activity is implicated in the modulation of insulin signaling and glucose homeostasis, making it a significant player in metabolic regulation and a potential target for the treatment of conditions like insulin resistance and type 2 diabetes. Furthermore, its involvement in cellular processes underscores its relevance in cancer biology, where its dysregulation may contribute to tumorigenesis and cancer progression. The critical role of INPPL1 in cellular signaling pathways highlights its potential as a therapeutic target for metabolic diseases and cancer.