FBXL17

FBXL17 (F-Box and Leucine-Rich Repeat Protein 17): FBXL17 is a member of the F-box protein family, which are critical components of the SCF (SKP1-cullin-F-box) complex, responsible for the ubiquitination and subsequent proteasomal degradation of target proteins. Through its role in protein turnover, FBXL17 regulates various cellular processes including cell cycle progression, signal transduction, and transcription. Its specific function involves the recognition and binding of phosphorylated substrates via its F-box motif and leucine-rich repeats, targeting them for ubiquitination. The precise regulation of protein levels by FBXL17 is essential for maintaining cellular homeostasis and function. Dysregulation of FBXL17 activity has been linked to cancer development and progression, making it a potential target for cancer therapeutics. By influencing the stability of key proteins, FBXL17 plays a pivotal role in controlling cell fate decisions and orchestrating cellular responses to environmental cues.