CBS

CBS (Cystathionine beta-synthase): CBS, an enzyme crucial for sulfur metabolism, plays a vital role in synthesizing cysteine from homocysteine. This process is essential for the production of glutathione, an antioxidant crucial for cellular defense against oxidative stress. Additionally, CBS is involved in the transsulfuration pathway, which regulates the levels of sulfur-containing amino acids and hydrogen sulfide, a signaling molecule with various physiological functions. Proper functioning of CBS is critical for maintaining cellular redox balance, modulating vascular tone, and regulating neurotransmitter synthesis. Dysregulation of CBS activity is associated with several metabolic disorders, including homocystinuria and cardiovascular diseases. Understanding the intricate mechanisms governing CBS activity holds promise for developing therapeutic interventions for conditions related to sulfur metabolism and oxidative stress.