ADAM10

ADAM10 (A Disintegrin and Metalloproteinase 10): ADAM10, a member of the ADAM (A Disintegrin And Metalloproteinase) family, is a transmembrane protease involved in diverse cellular processes such as cell adhesion, migration, and signaling. It functions primarily as a sheddase, cleaving the extracellular domain of various cell surface proteins, including growth factors, cytokines, adhesion molecules, and cell surface receptors. ADAM10-mediated proteolysis regulates crucial signaling pathways, including Notch, Eph, and cadherin signaling, influencing cell fate determination, tissue development, and homeostasis. Moreover, ADAM10 plays a pivotal role in synaptic plasticity and neurotransmission in the central nervous system. Dysregulation of ADAM10 activity has been implicated in various diseases, including cancer, Alzheimer's disease, and inflammatory disorders. Its ability to modulate the cell surface expression and activity of multiple signaling molecules highlights ADAM10's significance as a therapeutic target for diverse pathological conditions. Strategies aimed at modulating ADAM10 activity hold promise for the development of novel therapeutic interventions with potential implications in cancer therapy, neurodegenerative diseases, and inflammatory disorders.