DNA Methylation Plus Test

The DNA Methylation Plus test provides a detailed insight into your body's methylation processes by analyzing key genes. Methylation is a crucial biological process that influences gene expression, DNA repair, and detoxification pathways. It plays a significant role in various bodily functions and can impact everything from energy levels to mood and immune function. A DNA methylation test can be particularly beneficial for individuals interested in understanding their body's ability to process and detoxify, those experiencing health issues without clear causes, or anyone looking to optimize their overall health.

The test examines genes such as BHMT, MTHFR, COMT, AHCY, among others, providing insights into how your body regulates methylation. This process is essential for cell health and can influence risk factors for certain conditions, nutrient requirements, and the body's response to environmental toxins.

Genes in the DNA Methylation Test

Folate Cycle

These genes are involved in folate metabolism, a process crucial for DNA synthesis, repair, and methylation.

• DHFR – Catalyzes the conversion of dihydrofolate to tetrahydrofolate (THF), essential for DNA synthesis and cell growth.
• FOLH1 – Influences the conversion of folate to its active form, critical for methylation processes.
• MTHFR – A key gene in the folate cycle that converts 5,10-methylene-THF to 5-methyl-THF, the form of folate required for methionine synthesis.
• MTHFD1 – Supports the production of formate and tetrahydrofolate, impacting DNA methylation and synthesis.
• MTHFD1L – Affects mitochondrial folate metabolism and may play a role in epigenetic regulation.
• MTHFS – Catalyzes the conversion of formyl-THF to methenyltetrahydrofolate, influencing folate metabolism and methylation.
• SHMT1 – Involved in the conversion of serine to glycine, contributing to folate metabolism, DNA synthesis, and methylation.

Methionine Cycle

This cycle is essential for converting homocysteine to methionine and producing S-adenosylmethionine (SAM-e), one of the body's most important methyl donors.

• AHCY – Catalyzes the breakdown of S-adenosylhomocysteine (SAH) to homocysteine, a key process for methylation balance.
• BHMT – Helps recycle homocysteine into methionine by using betaine as a methyl donor.
• COMT – Responsible for the methylation and breakdown of catecholamines (e.g., dopamine and adrenaline), influencing stress response and mood.
• GNMT – Regulates S-adenosylmethionine (SAM-e) levels and contributes to methylation balance.
• MAT1A – Encodes methionine adenosyltransferase, which produces SAM-e, an essential molecule for methylation of DNA, proteins, and lipids.
• MTR – Encodes methionine synthase, which converts homocysteine into methionine with the help of vitamin B12.
• MTRR – Regenerates methylcobalamin, ensuring the continuous function of methionine synthase (MTR).
• PEMT – Essential for the production of phosphatidylcholine, supporting cell membrane stability and methylation processes by providing choline.
• TCN2 – Encodes transcobalamin II, a transport protein that delivers vitamin B12 to cells, crucial for methylation.

Transsulfuration & Related Processes

This section includes genes involved in converting homocysteine into sulfur-containing compounds and genes related to methylation and antioxidant defense.

• CBS – Regulates the breakdown of homocysteine via the transsulfuration pathway, influencing detoxification and antioxidant defense.
• CHDH – Encodes choline dehydrogenase, which converts choline to betaine, an essential cofactor for methylation and homocysteine metabolism.
• CUBN – Affects vitamin B12 absorption, crucial for methylation and detoxification processes.
• DNMT3B – Encodes an enzyme involved in DNA methylation and epigenetic regulation.
• FUT2 – Influences gut microbiota composition and may play a role in vitamin B12 metabolism.
• PDXK – Activates vitamin B6, an important cofactor in enzymatic reactions related to methylation and homocysteine metabolism.

How the Test Works

The DNA Methylation test is performed using a simple saliva sample collected at home. The process is straightforward:

1. Order the Test: Receive your DNA Methylation test kit delivered directly to your home.
2. Collect Your Sample: Follow the easy-to-use instructions to collect your saliva sample.
3. Send it Back: Use the prepaid return envelope to send your sample to our laboratory.
4. Receive Your Results: Within 6-8 weeks, you will get a detailed digital report outlining your methylation pathways along with personalized recommendations.

Why Test for DNA Methylation?

Methylation affects numerous bodily functions and can be a key factor in overall well-being. Understanding your methylation status can help you make informed decisions about your diet, lifestyle, and healthcare, potentially uncovering hidden health issues or optimizing your health strategy. This test is ideal for individuals who:

• Are curious about their genetic health.
• Want to optimize their diet and lifestyle based on their genetics.
• Experience unexplained health issues that may be related to methylation.

Sample & Data Privacy

Your DNA and sample material are destroyed after analysis. The sample is linked only to your unique test ID, ensuring complete anonymity. The laboratory does not have access to your identity, and we do not share results with third parties. You also have the option to delete your test results after receiving them.