TCN2

The TCN2 gene encodes transcobalamin II, a protein responsible for transporting vitamin B12 (cobalamin) from the bloodstream into cells. Once vitamin B12 is absorbed in the gut, it must bind to transcobalamin to be delivered to tissues where it is used for DNA synthesis, red blood cell formation, and neurological function. Genetic variations in TCN2 can reduce the efficiency of B12 transport, potentially leading to functional B12 deficiency even when blood levels appear normal. This may contribute to symptoms like fatigue, cognitive changes, or elevated homocysteine.

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Description

What does the TCN2 gene do?

It encodes the protein transcobalamin II, which binds and transports vitamin B12 into cells for biological use.

Why is TCN2 relevant in a health context?

Variants in this gene may reduce cellular uptake of B12, potentially affecting energy metabolism, nerve function, and methylation.

Can you have a B12 deficiency with normal blood levels if you have a TCN2 variant?

Yes, certain polymorphisms can impair transport into cells, leading to functional deficiency even if serum B12 appears sufficient.

What health symptoms may be associated with TCN2 variants?

Possible symptoms include fatigue, poor concentration, numbness or tingling, and elevated homocysteine levels.

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Content
What does the TCN2 gene do?
Why is TCN2 relevant in a health context?
Can you have a B12 deficiency with normal blood levels if you have a TCN2 variant?
What health symptoms may be associated with TCN2 variants?
What does the TCN2 gene do?
Why is TCN2 relevant in a health context?
Can you have a B12 deficiency with normal blood levels if you have a TCN2 variant?
What health symptoms may be associated with TCN2 variants?
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