MTHFR

MTHFR (Methylenetetrahydrofolate Reductase): MTHFR is a key enzyme involved in folate metabolism and the regulation of homocysteine levels in the body. This enzyme catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a crucial step in the remethylation of homocysteine to methionine. Methionine serves as a precursor for S-adenosylmethionine (SAM), a methyl donor essential for numerous methylation reactions in the body, including DNA methylation, neurotransmitter synthesis, and histone modification. Variants in the MTHFR gene, particularly the C677T and A1298C polymorphisms, have been associated with altered enzyme activity and folate metabolism. These variants can lead to elevated homocysteine levels and reduced availability of methyl...