TRIB3 (Tribbles Pseudokinase 3): TRIB3 is a pseudokinase that plays a key role in regulating multiple cellular signaling pathways involved in cell survival, metabolism, and stress responses. It helps modulate cellular stress by influencing pathways related to the unfolded protein response and insulin signaling. Elevated levels of TRIB3 have been associated with conditions such as insulin resistance, cardiovascular disease, and cancer by affecting cell proliferation and apoptosis.