Total Bile Acids
Total bile acids represent the combined concentration of all bile acids circulating in the blood. They are synthesised in the liver from cholesterol and play a central role in fat digestion, nutrient absorption, and detoxification. Elevated total bile acid levels may reflect reduced bile flow, liver dysfunction, or impaired reabsorption in the intestine. Normal concentrations indicate balanced bile acid synthesis and efficient hepatic and intestinal function.
Description
High total bile acid levels may indicate reduced bile flow (cholestasis), liver dysfunction, or impaired bile reabsorption in the intestine. Elevated concentrations can also occur when bile production or circulation is disrupted due to inflammation, toxins, or metabolic stress.
Testing can be valuable for individuals with digestive issues related to fat absorption, such as bloating, nausea after fatty meals, or pale stools. It can also help assess liver and gallbladder function in cases of chronic fatigue, hormonal imbalance, or suspected detoxification impairment.
Bile acid concentrations are affected by liver function, bile flow, gut microbiota composition, and cholesterol metabolism. Hormonal changes, certain medications, or imbalanced gut bacteria can also alter bile acid recycling between the liver and intestines.
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