TNP1
TNP1, or Transition Protein 1, is a protein primarily found in the nuclei of developing spermatids — the immature male germ cells — during spermiogenesis, the final stage of spermatogenesis where round spermatids mature into spermatozoa. TNP1 belongs to a family of small, highly basic transition proteins involved in chromatin remodeling during this process. Its main function is to facilitate the replacement of histones with protamines, which are specialized proteins that tightly compact DNA within the sperm nucleus.
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