TNFAIP3 (TNF Alpha Induced Protein 3): TNFAIP3, also known as A20, is a key negative regulator of NF-κB signaling, helping control inflammation and immune responses. It works by ubiquitinating signaling molecules to stop NF-κB activation, preventing prolonged inflammation that could lead to autoimmune disease. Mutations or dysregulation of TNFAIP3 are linked to various autoimmune and inflammatory conditions, making it an important focus of therapeutic research.