SMOC1 (SPARC Related Modular Calcium Binding 1): SMOC1 is a member of the SPARC family of matricellular proteins. It is involved in tissue remodeling and angiogenesis, playing a key role in cell-matrix interactions. SMOC1 has been linked to ocular and limb development, and mutations in this gene are associated with Waardenburg anophthalmia syndrome and other developmental disorders.