The SAMe/SAH ratio is a measure that reflects the balance between two important compounds in the body — S-Adenosylmethionine (SAMe) and S-Adenosylhomocysteine (SAH). SAMe serves as a key methyl donor in many biochemical processes, while SAH is produced after SAMe donates a methyl group. A higher SAMe/SAH ratio indicates strong methylation capacity, which supports healthy cellular function and overall well-being.
Testing the SAMe to SAH ratio can be beneficial for certain individuals, as this ratio is a marker of cellular methylation status and can indicate methylation imbalances. Groups that might benefit include:
A dysregulated SAMe/SAH ratio, indicating an imbalance in methylation processes, can lead to various symptoms, although these can be non-specific and overlap with other conditions:
Improving the SAMe/SAH ratio, which reflects the balance of methylation processes in the body, involves several dietary and lifestyle approaches:
Several factors can affect the SAMe/SAH ratio, influencing the body’s methylation processes: