NR3C2
NR3C2, also known as Nuclear Receptor Subfamily 3 Group C Member 2 or mineralocorticoid receptor (MR), is a nuclear receptor protein that plays a crucial role in the regulation of electrolyte balance and blood pressure homeostasis. Positioned predominantly within the cytoplasm of target cells, NR3C2 functions as a ligand-activated transcription factor that mediates the effects of mineralocorticoid hormones, such as aldosterone. One of the primary functions of NR3C2 is its involvement in the regulation of sodium and potassium ion transport in the kidney, colon, and salivary glands. Upon binding to aldosterone, NR3C2 undergoes a conformational change and translocates into the nucleus,...
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