NECTIN2 (Nectin Cell Adhesion Molecule 2): NECTIN2, also known as CD112, is a transmembrane protein in the nectin family that mediates cell-cell adhesion. It is mainly expressed in epithelial and neuronal tissues and interacts with other nectins and receptors like DNAM-1 (CD226), CD96, and TIGIT. NECTIN2 plays a key role in forming and maintaining adherens junctions and synaptic connections, influencing cell migration, polarization, and synaptic transmission.