MME, also known as Membrane Metallo-Endopeptidase or neprilysin, is a zinc-dependent metalloprotease enzyme that plays a key role in the regulation of peptide signaling molecules. It is primarily located on the cell membrane of various cell types, including neurons, endothelial cells, and immune cells. MME is especially important for degrading peptides involved in blood pressure regulation, such as bradykinin and atrial natriuretic peptide (ANP), converting them into inactive fragments and helping maintain cardiovascular homeostasis.