MCFD2 (Multiple Coagulation Factor Deficiency 2): MCFD2 is a gene that encodes a protein essential for the transport and proper folding of coagulation factors V and VIII, which are critical for blood clotting. Mutations in MCFD2 can lead to combined factor V and VIII deficiency, a rare bleeding disorder, highlighting its important role in hemostasis and the impact of disrupted protein transport on blood clotting.