Consultations

Consultations Website

GetTested Laboratory Test

GetTested Pet Test

GetTested Rapid Test

Supplements

The GetTested DNA Immunity & Inflammation test reveals your genetic tendencies towards inflammation, autoimmune diseases, allergies, and infections. By examining genes linked to conditions like CRP (inflammation), psoriasis, and gluten sensitivity (celiac disease), as well as your response to common allergens and pathogens, it offers a deep dive into how your immune system functions.

<p>The GetTested DNA Immunity & Inflammation test reveals your genetic tendencies towards inflammation, autoimmune diseases, allergies, and infections. By examining genes linked to conditions like CRP (inflammation), psoriasis, and gluten sensitivity (celiac disease), as well as your response to common allergens and pathogens, it offers a deep dive into how your immune system functions.</p>

DNA Immunity & Inflammation Test

PTPRM (Protein Tyrosine Phosphatase Receptor Type M): PTPRM is a receptor-type protein tyrosine phosphatase involved in cell signaling and regulation of tyrosine phosphorylation. It contributes to processes such as cell adhesion, migration, and neuronal development. Dysregulation of PTPRM has been linked to cancer progression and certain neuronal disorders.

PTPRM

NAV3 (Neuron Navigator 3): NAV3 is a gene involved in neuronal migration and axonal guidance, playing an important role in brain development. As part of the neuron navigator family, it contributes to the proper formation of neural networks. Changes in NAV3 have been associated with neurological disorders such as Alzheimer’s disease and schizophrenia, highlighting its importance in maintaining neural structure and function.

NAV3

LIN7C (Lin-7 Homolog C, Crumbs Cell Polarity Complex Component): LIN7C is a protein that reflects the role of the LIN7 family in establishing and maintaining cell polarity. It is essential for proper cell function and tissue organization, particularly in neural and epithelial cells. Mutations or dysregulation of LIN7C can disrupt cell polarity and signaling, potentially contributing to developmental abnormalities or disease.

LIN7C

MUC1 (Mucin 1): MUC1 is a gene that encodes a glycoprotein present on the surface of various epithelial cells, including those lining the respiratory and digestive tracts. It plays important roles in protection, lubrication, and cell signaling. Abnormal expression of MUC1 is linked to the development of several cancers.


MUC1

PDGFB (Platelet-Derived Growth Factor Subunit B): PDGFB is a gene that encodes a key growth factor involved in cell signaling and tissue repair. As part of the platelet-derived growth factor (PDGF) family, it plays an essential role in promoting cell proliferation, migration, wound healing, tissue remodeling, and the formation of new blood vessels (angiogenesis).

PDGFB

NRXN1 (Neurexin 1): NRXN1 is a neuronal cell adhesion molecule that reflects its role in synapse formation and function. It is essential for proper neural communication and has been associated with several neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, and intellectual disability.



NRXN1

PRRC2A (Proline-Rich Coiled-Coil 2A): PRRC2A is a protein-coding gene that plays a role in key cellular processes, including cell division and gene regulation. It contains proline-rich domains and coiled-coil regions, which are important for protein-protein interactions. While its precise functions are still being studied, PRRC2A is associated with certain cancers and may influence cell growth and differentiation.

PRRC2A

TOX3 (TOX High Mobility Group Box Family Member 3): TOX3 is a member of the high mobility group (HMG) box family and plays a role in transcriptional regulation. It has been studied in connection with breast cancer, as genetic variants in TOX3 have been linked to an increased risk of developing the disease.

TOX3

MRPS31 (Mitochondrial Ribosomal Protein S31): MRPS31 is a component of the mitochondrial ribosome, essential for mitochondrial protein synthesis. It plays a key role in producing proteins required for proper mitochondrial function and energy generation. Defects in MRPS31 can result in mitochondrial disorders that impact multiple body systems.


MRPS31

NUDT2 (Nudix Hydrolase 2): NUDT2 is an enzyme that regulates the balance of diadenosine polyphosphates, molecules involved in cellular signaling. It plays a key role in maintaining proper levels of these signaling molecules, which is important for various cellular processes, including stress responses and energy metabolism.


NUDT2

CAMK1G (Calcium/Calmodulin-Dependent Protein Kinase IG): CAMK1G is a member of the CaMK kinase family involved in calcium signaling pathways. This kinase is activated by calcium influx and calmodulin binding, triggering the phosphorylation of various proteins that regulate processes such as gene expression, cell cycle progression, and synaptic transmission. CAMK1G plays a key role in neuronal function and plasticity, contributing to learning and memory. Dysregulation of CAMK1G activity has been linked to neurological disorders, highlighting its critical role in maintaining neuronal health and signaling balance.



CAMK1G

CCDC171 (Coiled-Coil Domain Containing 171): CCDC171 is a gene characterized by the presence of a coiled-coil domain, which suggests a role in protein-protein interactions. While its specific function is not fully understood, genes with similar domains are commonly involved in cellular processes such as vesicle transport, cell division, and signal transduction.



CCDC171

ARHGAP27 (Rho GTPase Activating Protein 27): ARHGAP27 is a protein that reflects the regulation of actin cytoskeleton dynamics, cell morphology, and motility through its control of Rho GTPases. These GTPases are essential regulators of cellular processes including vesicle trafficking, cell cycle progression, and gene transcription. ARHGAP27’s role in modulating cell adhesion and migration is particularly important for tissue development, wound healing, and processes such as tumor progression and metastasis.




ARHGAP27

KLF14 (Krüppel-Like Factor 14): KLF14 is a transcription factor from the Krüppel-like factor family that regulates gene expression linked to key cellular processes. It plays an important role in metabolic regulation, particularly in adipocyte differentiation and lipid metabolism, affecting how the body stores and uses fats. KLF14 also contributes to glucose balance and insulin sensitivity, with dysregulation linked to metabolic disorders such as obesity and type 2 diabetes.

KLF14

INSIG1 (Insulin-Induced Gene 1): INSIG1 is a protein encoded by the INSIG1 gene that plays a key role in regulating lipid metabolism and cholesterol balance within cells. INSIG1 acts as a critical mediator of the feedback mechanism controlling cholesterol synthesis and uptake. It functions by binding to and inhibiting sterol regulatory element-binding proteins (SREBPs), transcription factors essential for the expression of genes involved in cholesterol and fatty acid production. By regulating SREBP activity, INSIG1 helps maintain proper cellular lipid levels and prevents excessive cholesterol accumulation.

INSIG1

TCERG1L (Transcription Elongation Regulator 1-Like): TCERG1L is a protein involved in the regulation of gene transcription, particularly during the elongation phase of RNA polymerase II activity. It plays a key role in ensuring accurate gene expression and influences the transcription of specific genes, thereby affecting cellular processes such as development and stress response. Understanding TCERG1L helps clarify the mechanisms of gene regulation and their relevance to diseases linked to transcriptional dysregulation.



TCERG1L

PTHLH (Parathyroid Hormone Like Hormone): PTHLH is a protein that plays a key role in bone and cartilage development. It acts similarly to parathyroid hormone and is involved in regulating bone remodeling and maintaining calcium homeostasis.

PTHLH

CELF2 (CUGBP Elav-Like Family Member 2): CELF2 is a member of the CUG-BP, Elav-like family of RNA-binding proteins, which play essential roles in regulating RNA processing, including alternative splicing, stability, and translation. CELF2 is involved in immune system development and function and has been linked to neurological disorders. Its role in post-transcriptional gene regulation makes it an important factor in cell differentiation and disease development, presenting potential targets for therapeutic intervention.



CELF2

MFSD10 (Major Facilitator Superfamily Domain-Containing Protein 10): MFSD10 is a gene that encodes a protein involved in transport processes across cell membranes. While its specific function is still under investigation, MFSD10 may play a role in nutrient transport and the maintenance of cellular homeostasis.

MFSD10 

RAP2B (RAP2B, Member of RAS Oncogene Family): RAP2B is a gene belonging to the RAS oncogene family, involved in intracellular signaling pathways that regulate cell proliferation, differentiation, and survival. It also plays a role in cytoskeletal organization and vesicle trafficking. Disruptions in RAP2B signaling may contribute to cancer development.

RAP2B

KCNMB3 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3): KCNMB3 is part of a family of calcium-activated potassium channels that help regulate neuronal excitability and vascular tone. This gene is important for blood pressure control and cardiovascular function, and variations in KCNMB3 may be associated with hypertension and heart disease.

KCNMB3

MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10): MAP3K10 is a member of the MAP3K family, also known as MLK2 (Mixed Lineage Kinase 2). This kinase plays a key role in cellular signaling pathways that regulate cell proliferation, differentiation, and apoptosis. MAP3K10 acts as an upstream activator of the MAP kinase (MAPK) cascade, translating extracellular signals into cellular responses. It is essential for neuronal function, immune regulation, and stress response, and dysregulation of MAP3K10 has been linked to various physiological and pathological conditions.



MAP3K10

INAVA (Innate Immune Signal Activator): INAVA is a gene involved in regulating the NF-kappaB signaling pathway, a key driver of the body’s innate immune responses. It plays an important role in activating immune cells and promoting the production of inflammatory mediators, helping the body defend against pathogens and manage inflammation.

INAVA

OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like): OPCML is a glycosylphosphatidylinositol-anchored protein involved in cell adhesion and signaling. It has been identified as a tumor suppressor, with its expression often reduced in various cancers, indicating a protective role against tumor development and progression.



OPCML

CLOCK (Circadian Locomotor Output Cycles Kaput): CLOCK is a gene that plays a key role in regulating circadian rhythms — the physical, mental, and behavioral changes that follow a 24-hour cycle. It helps control sleep-wake patterns and various physiological processes, including metabolism. Mutations in the CLOCK gene can disrupt normal circadian rhythms, contributing to sleep disorders, metabolic syndrome, and mood disturbances.

CLOCK

SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9): SCN9A encodes a voltage-gated sodium channel (NaV1.7) that is highly expressed in the peripheral nervous system, especially in pain-sensing neurons (nociceptors). Mutations in SCN9A can cause gain- or loss-of-function effects, leading to conditions such as erythromelalgia or congenital insensitivity to pain. As a key modulator of pain sensation, NaV1.7 is an important target for developing new analgesics.

SCN9A

CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B): CDKN2B is a gene that plays a key role in regulating the cell cycle by inhibiting cyclin-dependent kinases. It is essential for controlling the G1 phase of the cell cycle and preventing uncontrolled cell proliferation. Loss of CDKN2B function is commonly observed in various cancers, highlighting its role as a tumor suppressor and its potential as a target for cancer therapies.


CDKN2B

TNFAIP3 (TNF Alpha Induced Protein 3): TNFAIP3, also known as A20, is a key negative regulator of NF-κB signaling, helping control inflammation and immune responses. It works by ubiquitinating signaling molecules to stop NF-κB activation, preventing prolonged inflammation that could lead to autoimmune disease. Mutations or dysregulation of TNFAIP3 are linked to various autoimmune and inflammatory conditions, making it an important focus of therapeutic research.

TNFAIP3

MTHFD1 (Methylenetetrahydrofolate Dehydrogenase 1): MTHFD1 is a key enzyme in the folate metabolism pathway, catalyzing the conversion of tetrahydrofolate (THF) derivatives into forms used for the synthesis of DNA, RNA, and amino acids. It plays a vital role in one-carbon metabolism, influencing cellular methylation reactions and nucleotide production. Mutations or dysregulation of MTHFD1 can disrupt folate metabolism and are associated with an increased risk of congenital defects, cardiovascular diseases, and cancer.




MTHFD1

MTHFD2 (Methylenetetrahydrofolate Dehydrogenase 2): MTHFD2 is an enzyme that plays a key role in the mitochondrial one-carbon metabolic pathway. It is essential for nucleotide biosynthesis, methylation reactions, and amino acid homeostasis. MTHFD2 is highly expressed in rapidly dividing cells, including cancer cells, where it supports the production of purines and thymidylate, critical for DNA replication and repair. Its role in cellular metabolism and proliferation underscores its importance in growth and development, and its selective expression in tumors makes it a potential therapeutic target.

MTHFD2

PDE5A (Phosphodiesterase 5A): PDE5A is a gene that encodes an enzyme specifically targeting cyclic GMP (cGMP), a key second messenger in various biological processes. PDE5A plays an important role in regulating vascular smooth muscle, and its inhibitors are commonly used to treat erectile dysfunction and pulmonary hypertension. Research on PDE5A is significant for cardiovascular and urogenital health.

PDE5A

LANCL1 (LanC Like 1): LANCL1 is a gene that encodes a protein containing LanC (Lantibiotic Synthetase Component C-like) domains. Proteins with these domains are often involved in key cellular processes, including signal transduction, protein-protein interactions, and cellular regulation. The precise functions of LANCL1 are still being studied, and further research is needed to fully understand its role in cellular biology.

LANCL1

LAMP3 (Lysosomal Associated Membrane Protein 3): LAMP3 is a protein involved in lysosomal function and cell signaling. It plays a key role in the immune response, particularly in antigen presentation. Elevated levels of LAMP3 have been observed in various types of cancers, indicating a potential role in tumor progression and metastasis.

LAMP3

PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22): PTPN22 is an enzyme that reflects the regulation of immune responses in the body. It is a lymphoid-specific phosphatase that modulates T-cell receptor signaling and acts as a negative regulator of T-cell activation. PTPN22 is essential for maintaining immune tolerance and preventing autoimmune diseases. Genetic variations in PTPN22 have been associated with an increased risk of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus, highlighting its central role in immune regulation.

PTPN22

TPH2 (Tryptophan Hydroxylase 2): TPH2 is an enzyme that is crucial for the production of serotonin, a neurotransmitter that helps regulate mood, sleep, and appetite. TPH2 is mainly found in the brain and is key to central serotonin synthesis. Variations in the TPH2 gene have been associated with psychiatric disorders such as depression and bipolar disorders.

TPH2

OR5H14 (Olfactory Receptor Family 5 Subfamily H Member 14): OR5H14 is part of the olfactory receptor (OR) gene family, which is responsible for detecting and binding odor molecules. These receptors play a key role in the sense of smell. The specific ligands and precise function of OR5H14 in olfaction are not yet fully understood, but it contributes to the complexity and diversity of smell perception.



OR5H14

RHOBTB1 (Rho-Related BTB Domain Containing 1): RHOBTB1 is a member of the Rho GTPase family, involved in regulating diverse cellular processes such as cytoskeletal organisation, cell cycle progression, and gene expression. Unlike typical Rho GTPases, it has a distinctive structure that suggests roles in vesicular trafficking and signal transduction. Dysregulation of RHOBTB1 has been linked to certain cancers, indicating its potential as a biomarker or therapeutic target.

RHOBTB1

PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1): PTPMT1 is a mitochondrial phosphatase involved in the regulation of lipid metabolism and mitochondrial function. It plays a key role in the biosynthesis of cardiolipin, a phospholipid essential for mitochondrial membrane integrity and energy production. Dysregulation of PTPMT1 has consequences for metabolic diseases and is being investigated for its role in cancer metabolism, highlighting its importance in cellular energy homeostasis and disease.

PTPMT1

NEO1 (Neogenin 1): Neogenin 1 is a critical cell surface receptor involved in various cellular processes, including cell adhesion, migration, and axon guidance. It belongs to the immunoglobulin superfamily and plays a central role in nervous system development and the regulation of apoptosis. NEO1 functions as a receptor for netrin-1 and other ligands that control axonal growth and neuronal migration, which are essential for brain development. Additionally, it is involved in maintaining tissue homeostasis and vascular development. Mutations or dysregulation of NEO1 have been associated with a range of developmental disorders and diseases, including cancer progression and metastasis.

NEO1

RGS17 (Regulator Of G Protein Signaling 17): RGS17 is a gene that encodes a protein from the regulator of G protein signaling (RGS) family. These proteins help control G protein-coupled receptor (GPCR) signaling by speeding up the conversion of GTP to GDP. RGS17 may influence multiple GPCR-regulated pathways, impacting a variety of physiological processes.

RGS17

PSG9 (Pregnancy-Specific Glycoprotein 9): PSG9 is a gene that encodes a protein from the pregnancy-specific glycoprotein family, which is involved in immune regulation during pregnancy. These proteins may help support maternal tolerance of the fetus and contribute to fetal development. While the specific role of PSG9 is still being studied, it may influence reproductive health and pregnancy outcomes.

PSG9

PAPLN (Pappalysin 1): PAPLN is a gene associated with pregnancy-associated plasma protein-A (PAPP-A). PAPP-A is involved in pregnancy-related processes and plays a key role in regulating insulin-like growth factor (IGF) signaling.

PAPLN

PRDM5 (PR Domain Containing 5): PRDM5 is a transcription factor that plays a key role in regulating gene expression, cellular differentiation, and extracellular matrix organization. It is essential for the development and maintenance of tissues such as bone, cartilage, and connective tissue. Mutations in PRDM5 are associated with brittle cornea syndrome and other connective tissue disorders, underscoring its importance in tissue integrity and health.

PRDM5

KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11): KCNJ11 is a gene that encodes a protein forming part of the ATP-sensitive potassium (KATP) channel in pancreatic beta cells. These channels are essential for regulating insulin secretion and maintaining glucose homeostasis. Variations in KCNJ11 are linked to an increased risk of type 2 diabetes.

KCNJ11

PAPPA (Pregnancy-Associated Plasma Protein A): PAPPA is a protease that regulates the availability of insulin-like growth factors (IGFs) by cleaving their binding proteins. It plays a crucial role in fetal development and is used as a biomarker in prenatal screening for aneuploidies. Abnormal levels of PAPPA are associated with adverse pregnancy outcomes, including preeclampsia and intrauterine growth restriction.



PAPPA

HNRNPA1P48 (Heterogeneous Nuclear Ribonucleoprotein A1 Pseudogene 48): HNRNPA1P48 is a pseudogene related to the HNRNPA1 gene, which encodes a protein involved in mRNA processing and transport. While HNRNPA1P48 may not produce a functional protein, it could have regulatory roles in gene expression, such as generating non-coding RNAs or acting as decoys for regulatory molecules. Its precise functions are not fully understood, but its connection to HNRNPA1 suggests a potential role in RNA metabolism and regulation.

HNRNPA1P48

VEGFC (Vascular Endothelial Growth Factor C):VEGFC is a protein that plays a key role in lymphangiogenesis, the formation of lymphatic vessels, and angiogenesis, the formation of blood vessels. As part of the VEGF family, it contributes to processes such as embryonic development, tissue repair, and tumor progression. VEGFC stimulates the growth and proliferation of lymphatic endothelial cells, driving lymphatic vessel formation and remodeling. It primarily acts by binding to and activating VEGFR-3 (vascular endothelial growth factor receptor 3).

VEGFC

PTPRC (Protein Tyrosine Phosphatase, Receptor Type C): PTPRC is a protein that reflects a key regulator of the immune system. Also known as CD45, it is a transmembrane protein tyrosine phosphatase essential for activating T and B lymphocytes. PTPRC plays a critical role in modulating signal transduction pathways, and its dysregulation can contribute to immune system disorders.




PTPRC

MRPS18C (Mitochondrial Ribosomal Protein S18C): MRPS18C is a component of the mitochondrial ribosome, essential for mitochondrial protein synthesis. It plays a key role in producing proteins that are part of the mitochondrial respiratory chain. Dysfunction in MRPS18C can impact mitochondrial function and energy metabolism, potentially contributing to mitochondrial disorders.



MRPS18C

CACNA1D (Calcium Voltage-Gated Channel Subunit Alpha1 D): CACNA1D is a gene that encodes a subunit of the L-type voltage-dependent calcium channel, which is essential for regulating calcium influx in various cell types, especially in muscle and nerve cells. Mutations in this gene have been linked to conditions such as autism spectrum disorders, epilepsy, and certain cardiac dysfunctions.

CACNA1D

PVR (Poliovirus Receptor): PVR is a transmembrane glycoprotein that functions as a receptor for poliovirus and related enteroviruses, facilitating viral entry and infection. Beyond its role in viral recognition, PVR is essential for cell-cell adhesion, immune regulation, and tissue homeostasis. It contributes to the integrity of epithelial and endothelial barriers through its involvement in adherens and tight junctions. Interactions of PVR with ligands such as TIGIT and DNAM-1 help regulate immune cell activation, influencing both innate and adaptive immune responses. Dysregulation of PVR expression or function can have significant impacts on immune function and tissue integrity.

MPO (Myeloperoxidase): MPO is an enzyme primarily expressed in neutrophils and plays a key role in the body’s defense system. It generates hypochlorous acid and other reactive molecules from hydrogen peroxide to combat bacteria and pathogens. While essential for immune defense, MPO activity can also contribute to tissue damage during inflammation and has been linked to diseases, including cardiovascular conditions, through its role in oxidative stress.

TMPRSS4 (Transmembrane Protease, Serine 4): TMPRSS4 is a member of the transmembrane serine protease family, located on the cell surface and involved in activating proteins by cleaving peptide bonds. TMPRSS4 plays important roles in physiological and pathological processes, including cell migration, invasion, and the regulation of epithelial-mesenchymal transition (EMT), which is critical for development, wound healing, and cancer metastasis. Its overexpression has been linked to the progression of various cancers, making TMPRSS4 a potential biomarker for cancer diagnosis and prognosis.

TMPRSS4

SARDH (Sarcosine Dehydrogenase): SARDH is an enzyme involved in the metabolism of sarcosine, an intermediate in the conversion of choline to glycine. It plays a key role in one-carbon metabolism, which is important for processes such as DNA methylation. Dysfunctions in SARDH can impact metabolic pathways and have been linked to certain metabolic disorders.




SARDH

RWDD3 (RWD Domain Containing 3): RWDD3 is a protein whose function is not yet well understood. It is under investigation for its potential roles in cellular processes and its relevance to human health and disease.

RWDD3

THNSL2 (Threonine Synthase-Like 2): THNSL2 is an enzyme potentially involved in amino acid metabolism, particularly in the synthesis of threonine. Its precise role and significance in human metabolism and disease are not yet fully understood.



THNSL2

NFE2 (Nuclear Factor, Erythroid 2): NFE2 is a transcription factor that regulates genes involved in erythropoiesis, the production of red blood cells. It plays a key role in the development and maturation of erythroid cells. Changes or mutations in NFE2 can impact red blood cell production and may contribute to blood disorders.

NFE2

OXTR (Oxytocin Receptor): OXTR is a gene that encodes the receptor for oxytocin, a hormone involved in social bonding, sexual reproduction, childbirth, and maternal behaviors. It plays a key role in regulating social interactions and trust, and dysregulation may contribute to conditions such as autism and social anxiety disorders.

OXTR

OR10J5 (Olfactory Receptor 10J5): OR10J5 is a gene that encodes a protein belonging to the olfactory receptor family, which is essential for the sense of smell. This receptor detects specific odor molecules and contributes to the perception of a wide range of scents. Studying OR10J5 helps improve our understanding of olfaction and may inform the development of sensory-related technologies and fragrance design.

OR10J5

TNFRSF11B (Tumor Necrosis Factor Receptor Superfamily Member 11B): TNFRSF11B is a protein, also known as osteoprotegerin, that plays a key role in bone metabolism. It acts as a decoy receptor for RANKL, helping to inhibit osteoclast formation and prevent bone resorption. TNFRSF11B is essential for maintaining bone density and strength, and changes in its function are associated with osteoporosis and other bone disorders.

TNFRSF11B

TP63 (Tumor Protein P63): TP63 is a member of the p53 family of transcription factors that plays a key role in the development and maintenance of epithelial tissues, as well as in cell cycle control and programmed cell death. It is involved in embryonic development, stem cell maintenance, and tumorigenesis. Mutations in TP63 can cause various developmental disorders and have been linked to certain cancers. Research continues to explore its dual roles in normal cell function and disease.

TP63

TMEM245 (Transmembrane Protein 245): TMEM245 is a protein located in the cell membrane, though its precise functions remain unclear. It may participate in processes related to membrane dynamics or intracellular trafficking. Further research is needed to clarify its role in cellular physiology and its potential links to disease.

TMEM245

NDRG2 (N-Myc Downstream Regulated Gene 2): NDRG2 is a gene involved in regulating cell growth and differentiation. It functions as a tumor suppressor and plays a key role in stress responses and the inhibition of cell proliferation. NDRG2 is particularly important for brain and nervous system development, and its dysregulation has been linked to multiple types of cancer.

NDRG2

RTN4 (Reticulon 4): RTN4 is a protein, also known as Nogo, that plays a key role in regulating nerve fiber growth in the central nervous system. It is significant in the context of spinal cord injury and neurodegenerative diseases, as it can inhibit axon regeneration. RTN4 has been a focus of research aimed at promoting neural repair and regeneration.

RTN4

TMEM72 (Transmembrane Protein 72): TMEM72 is a transmembrane protein whose functions are not yet fully characterized. Like other transmembrane proteins, TMEM72 is believed to play roles in cellular signaling, transport, and communication. Its specific involvement in cellular processes and potential implications in human diseases are currently under investigation.

TMEM72

RALGPS2 (Ras Protein Activator Like GTPase 2): RALGPS2 is a gene that encodes a protein involved in activating Ras GTPases, which are key regulators of cell growth and differentiation. By promoting Ras GTPase activity, RALGPS2 plays a role in cellular signaling pathways that govern essential processes such as cell proliferation and survival.

RALGPS2

HGF (Hepatocyte Growth Factor): Hepatocyte Growth Factor (HGF) is a multifunctional growth factor that influences various cells by promoting cell growth, motility, and morphogenesis. It plays a key role in liver regeneration as a powerful mitogen for hepatocytes and is involved in wound healing and tissue repair. HGF’s ability to stimulate cell growth and migration also makes it important in cancer research, where it can affect tumor growth and metastasis. The therapeutic potential of HGF and its inhibitors is a major focus in regenerative medicine and oncology.

ZNF584 (Zinc Finger Protein 584): ZNF584 is a member of the zinc finger protein family, typically involved in DNA binding and gene regulation. Although its specific functions are not fully defined, ZNF584 may contribute to transcriptional regulation, affecting various cellular processes and potentially influencing developmental pathways or disease mechanisms.

ZNF584

MRPS9 (Mitochondrial Ribosomal Protein S9): MRPS9 is a component of the mitochondrial ribosome, essential for the synthesis of proteins within mitochondria. It plays a vital role in producing proteins required for mitochondrial function and energy generation. Impairments in MRPS9 can reduce mitochondrial efficiency and may be associated with mitochondrial disorders, influencing overall cellular energy metabolism.



MRPS9

MICAL2 (Molecule Interacting with CasL 2): MICAL2 is an enzyme that belongs to the MICAL family, known for regulating cytoskeletal dynamics through the oxidation of actin. MICAL2 plays a key role in controlling actin filament disassembly, which affects cell shape, migration, and intracellular transport. Its activity is essential for processes such as neurite outgrowth, axon guidance, and the maintenance of synaptic and vascular structures. By modulating the cytoskeleton, MICAL2 supports cell communication, differentiation, and movement. Dysregulation of MICAL2 has been associated with cancer progression, neurological disorders, and vascular diseases.



MICAL2

PTPRT (Protein Tyrosine Phosphatase, Receptor Type T): PTPRT is a gene that encodes a protein belonging to the protein tyrosine phosphatase family, which is important for cell signaling. It plays a role in regulating cellular processes such as cell growth and differentiation. Mutations in PTPRT have been linked to several cancers, particularly colorectal cancer, due to its involvement in signaling pathways that control cell proliferation.

PTPRT

NUDT12 (Nudix Hydrolase 12): NUDT12 is an enzyme that helps maintain cellular health by hydrolyzing oxidized nucleotides, preventing their incorporation into DNA and RNA. It plays a key role in protecting cells from oxidative damage and in maintaining genomic integrity and cellular redox balance.

NUDT12

PTGER4 (Prostaglandin E Receptor 4): PTGER4 is a gene that encodes a receptor for prostaglandin E2 (PGE2), a lipid mediator involved in inflammation and immune responses. PTGER4 plays a key role in regulating immune cell activation, cytokine production, and other cellular functions, influencing the body’s inflammatory processes. It has been studied in the context of autoimmune and inflammatory diseases.

PTGER4

MRO (Maestro Heat-Like Repeat Family Member): MRO is a protein containing a maestro heat-like repeat, indicating a potential role in the heat shock response or cellular stress adaptation. Its exact functions in human physiology and possible links to disease remain unclear, making it an active area of ongoing research.

SESN3 (Sestrin 3): SESN3 is a member of the sestrin family of stress-responsive proteins. It is involved in regulating cell growth and metabolism, particularly under conditions of cellular stress. SESN3 also contributes to antioxidant defense and has been associated with metabolic regulation, with potential implications for conditions such as obesity and diabetes.

SESN3

MROH8 (Maestro Heat Like Repeat Family Member 8): MROH8 is a gene that encodes a protein containing heat-like repeat domains, which are involved in mediating protein-protein interactions. Its specific biological role is not yet fully understood and remains under investigation.

MROH8

LRRC37A (Leucine Rich Repeat Containing 37A): LRRC37A is a gene located in a complex genomic region and is associated with brain development. It has been linked to neurodevelopmental disorders, such as autism spectrum disorder, though its precise role and underlying mechanisms remain under investigation.

LRRC37A

THEMIS2 (Thymocyte Selection Associated Family Member 2): THEMIS2 is a gene primarily expressed in immune cells and involved in regulating innate immune responses. It participates in signaling pathways that influence the activation and function of macrophages and B cells. Its role in immune regulation points to potential involvement in inflammatory diseases and makes it a possible target for modulating immune activity in autoimmunity and infection.

THEMIS2

EDA2R, also known as Ectodysplasin A2 receptor, is a protein encoded by the EDA2R gene. It belongs to the tumor necrosis factor receptor (TNFR) superfamily and serves as a receptor for ectodysplasin A2 (EDA-A2), a signaling molecule. EDA2R plays a key role in mediating EDA-A2 signaling during embryonic development, which regulates the formation and patterning of ectodermal tissues such as hair, teeth, and sweat glands.



EDA2R

GPR25 (G Protein-Coupled Receptor 25): GPR25 is a receptor belonging to the G protein-coupled receptor family. It is involved in physiological processes such as signal transduction and cell communication. While its precise roles in human health and disease remain under investigation, it is thought to contribute to diverse cellular functions.

GPR25

MYH6 (Myosin Heavy Chain 6): MYH6 is a gene that encodes the alpha heavy chain subunit of cardiac myosin, a motor protein in the heart muscle. This protein is essential for cardiac muscle contraction, enabling the heart to pump blood effectively throughout the body. The alpha heavy chain plays a key role in atrial contraction, supporting the initial filling phase of the ventricles. Mutations in MYH6 have been associated with various cardiac disorders, including atrial septal defects, cardiomyopathies, and heart rhythm abnormalities, highlighting its critical role in heart function and development.


MYH6

PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1): PMAIP1,also known as Noxa, is a pro-apoptotic protein that plays a key role in regulating programmed cell death (apoptosis). It functions within the intrinsic apoptosis pathway and helps trigger cell death in response to cellular stress. PMAIP1 has important implications in cancer therapy, as its activation can increase the sensitivity of cancer cells to apoptosis-inducing treatments.

PMAIP1

MDGA1 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 1): MDGA1 is a protein involved in neural development and cell adhesion. It plays a key role in axon guidance and contributes to neural connectivity and synaptic function.



MDGA1

MKNK2 (MAP Kinase Interacting Serine/Threonine Kinase 2): MKNK2 is a gene that encodes a kinase interacting with MAP kinases. It plays a key role in regulating protein synthesis and is involved in multiple cellular processes, including stress responses and inflammation. Dysregulation of MKNK2 has been associated with cancer and other diseases related to abnormal signaling pathways.



MKNK2

RPS20 (Ribosomal Protein S20): RPS20 is a ribosomal protein that plays a key role in ribosome assembly and protein synthesis. It is a component of the small ribosomal subunit and is essential for proper translation. Mutations in RPS20 and other ribosomal proteins can lead to ribosomopathies, a group of disorders marked by defective ribosome function and developmental abnormalities.


RPS20

RTL1 (Retrotransposon Like 1): RTL1 is a gene believed to originate from a retrotransposon and plays a key role in placental development. It exhibits imprinted expression, meaning it is active from only one parental allele. Dysregulation of RTL1 can contribute to disorders associated with genomic imprinting, such as Beckwith-Wiedemann syndrome.



RTL1

MAGI3 (Membrane Associated Guanylate Kinase, WW, and PDZ Domain Containing 3): MAGI3 is a scaffolding protein that plays a key role in the assembly of multiprotein complexes at cell junctions and in signal transduction pathways. It is involved in cellular processes such as epithelial cell polarity and may contribute to cancer development, particularly through its roles in cell-cell adhesion and signaling.

MAGI3

HNMT (Histamine N-Methyltransferase): HNMT is an enzyme responsible for inactivating histamine through methylation. It plays a key role in histamine metabolism, and variations in this gene can influence histamine-related pathways, affecting allergic responses and other conditions linked to histamine.

HNMT

TIAM2, also known as T-lymphoma invasion and metastasis-inducing protein 2, is a key member of the TIAM family of guanine nucleotide exchange factors (GEFs). Primarily located in the cytoplasm, TIAM2 is essential for regulating cellular processes, especially those involving cytoskeletal dynamics, cell migration, and invasion. A defining feature of TIAM2 is its role as a molecular switch for activating Rho GTPases, particularly Rac1. Through its GEF activity, TIAM2 facilitates the exchange of GDP for GTP on Rac1, triggering downstream signaling pathways that control actin cytoskeleton rearrangements.


TIAM2

SEMA6D (Semaphorin 6D): SEMA6D is a gene that encodes a protein belonging to the semaphorin family, which is involved in axon guidance and neural development. SEMA6D plays a role in neuronal signaling and migration during development. It may influence the formation of neural circuits and has implications in neurodevelopmental disorders.

SEMA6D

PPP6R2 (Protein Phosphatase 6 Regulatory Subunit 2): PPP6R2 is a gene that encodes a regulatory subunit of protein phosphatase 6 (PP6). PP6 is involved in the dephosphorylation of target proteins and plays key roles in cell cycle regulation, DNA damage repair, and cellular signaling. PPP6R2 helps modulate the activity and specificity of PP6, influencing these critical cellular processes.

PPP6R2

SBF2 (SET Binding Factor 2): SBF2 is a protein involved in nerve development and function. It plays a key role in maintaining the structure and health of peripheral nerves. Mutations in SBF2 have been linked to Charcot-Marie-Tooth disease, a hereditary neurological disorder that can cause nerve degeneration, muscle weakness, and sensory loss.




SBF2

MC4R (Melanocortin 4 Receptor): MC4R is a G protein-coupled receptor that plays a key role in regulating energy balance, appetite, and body weight. Mutations in MC4R are among the most common genetic causes of obesity, highlighting its importance in controlling energy homeostasis. It is also a target for developing obesity treatments.

MC4R

MDFI (MyoD Family Inhibitor): MDFI is a gene involved in regulating muscle differentiation and development. It functions as an inhibitor of MyoD family transcription factors, which are key regulators of myogenesis. By modulating their activity, MDFI helps control muscle cell proliferation and differentiation, playing a vital role in muscle formation and repair. Dysregulation of MDFI can impact muscle development and regeneration.

MDFI

PRIMA1 (Proline Rich Membrane Anchor 1):PRIMA1 is a gene that encodes a protein involved in anchoring acetylcholinesterase to neuronal membranes. This protein plays a key role in the breakdown of the neurotransmitter acetylcholine and is important for regulating cholinergic neurotransmission. It is also of interest in research on neurodegenerative diseases such as Alzheimer's.

PRIMA1

PRELID1 (Prelamin A-Related Integral Membrane Protein 1): PRELID1 is a gene involved in nuclear envelope biology. It plays a key role in the processing of prelamin A, the precursor to lamin A, which is an essential structural component of the nuclear envelope. Proper PRELID1 function is critical for maintaining nuclear structure and integrity, and alterations in this gene may affect nuclear organization and cellular function.




PRELID1

MAML3 (Mastermind-Like Transcriptional Coactivator 3): MAML3 is a gene that reflects its role in transcriptional coactivation. It interacts with multiple transcription factors to enhance their activity, thereby influencing gene expression patterns. MAML3 is important for transcriptional regulation and is implicated in developmental processes and cell differentiation.



MAML3

PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha): PIK3C2A is a member of the PI3K family and a key regulator in cell signaling pathways that control cell growth and survival. It is involved in membrane trafficking, insulin signaling, and cytoskeletal dynamics. Dysregulation of PIK3C2A can contribute to the development of diseases such as cancer and metabolic disorders.

LMNB1

Your Cart

Tests containing this item

Trusted by over 100.000+ customers