KLF6, or Krüppel-Like Factor 6, is a transcription factor that belongs to the Krüppel-like family of zinc finger proteins. It plays key roles in regulating gene expression, cell proliferation, differentiation, apoptosis, and various biological processes related to development, tissue maintenance, and disease. KLF6 functions primarily as a transcriptional regulator by binding to specific DNA sequences called Krüppel-like factor binding sites, thereby influencing the transcriptional activity of target genes. Depending on the cellular environment, KLF6 can act as either a transcriptional activator or repressor.