Hydroxymethylglutarate (HMG), especially as β-hydroxy β-methylglutaryl-CoA (HMG-CoA), is a compound that plays two vital roles in the body. It is a key intermediate in cholesterol synthesis, necessary for creating cell membranes, steroid hormones, and bile acids. Additionally, in the liver, HMG-CoA contributes to producing ketone bodies, which serve as an alternative energy source during fasting, low-carbohydrate diets, or intense exercise when glucose levels are low.
Testing for hydroxymethylglutarate (HMG) might benefit certain individuals:
Dysregulated hydroxymethylglutarate (HMG) levels, particularly in the context of its role in cholesterol synthesis and ketone body production, can be indicative of underlying metabolic imbalances. While specific symptoms can vary depending on the nature and extent of the dysregulation, common signs might include:
Regulating hydroxymethylglutarate (HMG) levels in the body, particularly in the context of its role in cholesterol synthesis and ketone body production, involves managing overall metabolic health. Some general strategies can support healthy metabolic function, which in turn can help maintain appropriate HMG levels:
Several factors can affect hydroxymethylglutarate (HMG) levels in the body, particularly since HMG is involved in crucial metabolic pathways like cholesterol synthesis and ketone body production. Key factors include: