FLNB (Filamin B): FLNB is a gene that encodes a protein essential for cross-linking actin filaments in the cytoskeleton. This protein plays a key role in maintaining the structure and function of cells. Mutations in FLNB lead to a group of skeletal disorders called filaminopathies, which include conditions such as spondylocarpotarsal synostosis syndrome and Larsen syndrome, characterized by skeletal malformations and joint dislocations.