FGD4 (FYVE, RhoGEF, and PH Domain Containing 4): FGD4 is a gene that encodes a guanine nucleotide exchange factor responsible for specifically activating Cdc42, a member of the Rho family of GTPases. This activation is essential for regulating cytoskeletal organization, cell shape, and migration. Mutations in FGD4 are linked to Charcot-Marie-Tooth disease, a disorder affecting peripheral nerves, underscoring its critical role in nerve development and function.
