Cytotoxic / Neuroprotective Bile Acids (Ratio)
This ratio represents the relationship between more cytotoxic bile acids (e.g., lithocholic and deoxycholic acid) and protective bile acids such as ursodeoxycholic acid (UDCA). An elevated ratio may suggest increased oxidative or inflammatory stress in the liver or gut environment. A lower ratio, with higher levels of neuroprotective bile acids, indicates better bile acid homeostasis and reduced cellular stress. Balanced values support optimal liver detoxification and metabolic resilience.
Description
This ratio reflects the balance between potentially harmful (cytotoxic) bile acids—such as lithocholic and deoxycholic acid—and protective bile acids like ursodeoxycholic acid (UDCA). It provides insight into oxidative, inflammatory, and metabolic stress affecting the liver–gut axis.
A higher ratio may indicate increased oxidative or inflammatory stress, impaired bile acid detoxification, or reduced conversion of toxic bile acids into protective forms. It can also reflect microbial imbalance or excessive bile acid production.
A lower ratio generally suggests greater hepatobiliary protection, efficient bile acid recycling, and reduced cellular stress. It may be seen when UDCA levels are sufficient to buffer against cytotoxic bile acids.
Supporting liver detoxification, maintaining gut microbial balance, and ensuring adequate antioxidant intake can help modulate this ratio. Nutrients like taurine, glycine, and phosphatidylcholine, along with a balanced diet and hydration, support bile acid homeostasis and metabolic resilience.
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