ADMA (Asymmetric Dimethylarginine)
ADMA is an endogenous inhibitor of nitric oxide synthase (NOS), the enzyme responsible for producing nitric oxide (NO), a key molecule for vascular tone and endothelial function. Elevated ADMA levels can reduce nitric oxide availability, potentially affecting blood vessel dilation and circulation. Increased concentrations have been associated with endothelial dysfunction and impaired blood flow regulation. Low or balanced ADMA levels generally indicate healthy nitric oxide production and vascular function.
Description
High ADMA levels may not cause direct symptoms, but they can contribute to reduced nitric oxide availability, leading to poor blood vessel dilation. Over time, this may manifest as fatigue, cold extremities, elevated blood pressure, or signs of endothelial dysfunction.
Testing ADMA can be particularly useful for individuals with cardiovascular risk factors such as hypertension, high cholesterol, diabetes, obesity, or metabolic syndrome. It may also be valuable for those with symptoms of poor circulation or chronic fatigue of unclear origin.
ADMA levels are influenced by oxidative stress, inflammation, and impaired methylation or renal function. Lifestyle factors such as poor diet, smoking, and lack of physical activity can also elevate ADMA.
In many cases, yes. Reducing oxidative stress, supporting endothelial health, and maintaining good kidney and methylation function can help normalize ADMA levels. Nutrients like L-arginine, L-citrulline, folate, and vitamin B12 are involved in pathways related to nitric oxide synthesis and methylation balance.
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