ACKR1 (Atypical Chemokine Receptor 1): ACKR1 is a receptor that reflects the body’s regulation of chemokine activity. Formerly known as DARC (Duffy Antigen Receptor for Chemokines), ACKR1 acts as a decoy receptor, binding chemokines without triggering intracellular signaling. By sequestering chemokines, it helps modulate immune responses and control inflammation, protecting tissues from excessive damage. Variations in ACKR1 are linked to differences in infection susceptibility and the severity of inflammatory diseases.