Anti-Thyroid Peroxidase (A-TPO) antibodies are immune proteins that mistakenly target thyroid peroxidase, an enzyme essential for producing thyroid hormones. Elevated levels of A-TPO antibodies are often associated with autoimmune thyroid disorders such as Hashimoto’s thyroiditis and Graves’ disease, which can lead to either underactive or overactive thyroid function and affect overall health.
Individuals with symptoms of thyroid dysfunction, a family history of thyroid disease, or other autoimmune conditions should consider A-TPO testing.
High A-TPO levels often indicate an autoimmune thyroid disorder, such as Hashimoto’s thyroiditis or Graves’ disease, where the immune system attacks the thyroid.
Rarely, individuals may have elevated A-TPO levels without clear signs of thyroid disease, but it usually warrants further monitoring and evaluation.
Yes, A-TPO levels can fluctuate, especially in response to thyroid disease progression or treatment.