TRDMT1

TRDMT1 (tRNA (cytosine(38)-C(5))-methyltransferase): TRDMT1 is an enzyme responsible for catalyzing the methylation of cytosine at position 38 in tRNA molecules. This post-transcriptional modification, known as 5-methylcytosine (m5C), is essential for the stability and proper function of tRNA. Methylation of cytosine at position 38 contributes to tRNA folding, stability, and accurate codon recognition during translation. TRDMT1-mediated tRNA methylation plays crucial roles in various cellular processes, including protein synthesis, regulation of gene expression, and cellular stress responses. Dysregulation of TRDMT1 activity or tRNA methylation has been implicated in several human diseases, including cancer, neurodegenerative disorders, and developmental abnormalities. Additionally, TRDMT1 has been shown...

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