Secondary bile acids
Secondary bile acids are formed in the colon through bacterial transformation of primary bile acids originally synthesized in the liver. While they play roles in digestion and microbial regulation, elevated levels may signal dysbiosis, excessive fat intake, or altered bile acid metabolism. Some secondary bile acids, such as deoxycholic acid (DCA) and lithocholic acid (LCA), have been associated with mucosal irritation, inflammation, and increased risk for colorectal disorders when persistently elevated. Measuring them in stool helps assess gut microbial activity and bile detoxification status.
Description
They are bile acids formed by intestinal bacteria from primary bile acids that originate in the liver.
To evaluate microbial activity, fat digestion, and potential mucosal effects related to bile acid transformation.
It can indicate dysbiosis, high fat intake, or slowed intestinal transit, and may contribute to gut inflammation.
Not necessarily. In small amounts they aid digestion, but chronically elevated levels may be irritating or pro-inflammatory.
Diet (especially fat and fiber), microbial composition, and bile acid recycling efficiency all play a role.
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