NOTCH1 (Notch Receptor 1): NOTCH1 is a key component of the Notch signaling pathway, which plays an important role in cell fate determination, stem cell maintenance, and differentiation during both embryonic and adult tissue development. Dysregulation of NOTCH1 signaling is linked to various disorders, including several cancers like T-cell acute lymphoblastic leukemia, as well as developmental abnormalities. Its broad influence on cell proliferation and differentiation makes NOTCH1 a significant focus in developmental biology and oncology research.
