Isocitrate is a key intermediate in the Krebs cycle, an essential metabolic pathway for cellular energy production. It is formed from citrate and then converted into α-ketoglutarate, a step that helps generate NADH used for ATP synthesis. Isocitrate also connects multiple metabolic processes, including the production of amino acids, nucleotides, and fatty acids.
Testing for isocitrate might benefit certain individuals under specific circumstances:
Dysregulated isocitrate levels, particularly in the context of the Krebs cycle and cellular metabolism, can be indicative of broader metabolic disturbances. Symptoms might include:
Regulating isocitrate levels in the body is primarily achieved through maintaining overall metabolic health. Here are some general strategies:
Several factors can affect isocitrate levels in the body, primarily related to overall metabolic health and cellular function. Key factors include: