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Persistent fatigue and thyroid issues are often linked to B12 levels. While a standard B12 test might show normal total levels, it is the active form of B12, which makes up only 10-30% of the total, that plays a vital role in your health. GetTested’s Vitamin B12 Test specifically measures this active form. For a more comprehensive health assessment, our Vitamin Test includes standard B12, folate, vitamins D and E, and CoQ10, providing a detailed nutrient profile for those looking to address fatigue.

Persistent fatigue and thyroid issues are often linked to B12 levels. While a standard B12 test might show normal total levels, it is the active form of B12, which makes up only 10-30% of the total, that plays a vital role in your health. GetTested’s Vitamin B12 Test specifically measures this active form. For a more comprehensive health assessment, our Vitamin Test includes standard B12, folate, vitamins D and E, and CoQ10, providing a detailed nutrient profile for those looking to address fatigue.

Vitamin B12 Test

Vitamins

Nicotinic acid (niacin or vitamin B3) is an essential nutrient that helps convert food into energy and supports healthy skin, nerve function, and digestion. It’s naturally found in foods like meat, fish, and grains, and can also be made from the amino acid tryptophan. A deficiency in nicotinic acid can cause pellagra, a condition marked by diarrhea, dermatitis, and dementia.

Nicotinic acid

Vitamin E is a fat-soluble antioxidant that helps protect cells from damage and supports immune function. It also plays a key role in maintaining healthy skin and blood vessels. Vitamin E is commonly found in foods such as vegetable oils, nuts, seeds, and green leafy vegetables. Although deficiency is uncommon, it can lead to neurological problems.

Vitamin E

Vitamin B12, or cobalamin, is a water-soluble vitamin essential for red blood cell formation, nervous system health, and energy metabolism. It's unique in containing the metal cobalt and is found naturally in animal products like meat, fish, poultry, eggs, and dairy. Vegetarians and vegans may need fortified foods or supplements, as B12 is scarce in plant-based diets....

Vitamin B12

Q10, or CoQ10, is a crucial compound for energy production in every human cell and also acts as an antioxidant to protect cells from damage. It's vital for maintaining overall health and cellular function....

Coenzyme Q10

Folate, also known as folic acid, is vital for cell growth and making DNA. It's key for pregnant women to prevent birth defects. Folate is in leafy greens, fruits, beans, and fortified foods. Supplements are common for pregnancy and some health conditions. A lack of folate can lead to tiredness and weak immunity....

Folate (folic acid)

Biotin, or vitamin B7, is vital for turning food into energy and supports healthy skin, hair, and nails. It's key in metabolizing fats, carbohydrates, and proteins. Biotin deficiency is rare, but supplements are often used to enhance hair and nail health....

Biotin

Nicotinamide, also known as niacinamide, is a form of vitamin B3. It's essential for cellular metabolism and is involved in skin, nervous system, and digestive health. Unlike nicotinic acid, another form of vitamin B3, nicotinamide doesn't cause skin flushing. It's used in treating skin conditions like acne and is being studied for potential benefits in neurodegenerative diseases and cancer prevention. Found in foods like meat, fish, and green vegetables, nicotinamide is also available as a supplement and is commonly used in skincare products....

Nicotinamide

Vitamin B5, also known as pantothenic acid, is key for making energy from food. It helps the body use carbs, proteins, and fats. B5 is in meats, avocados, broccoli, and whole grains. It's rare to lack B5, but it's important for skin health and wound healing. B5 supports the nervous system and reduces stress....

Vitamin B5

Vitamin D is a fat-soluble vitamin essential for maintaining healthy bones and teeth, supporting the immune system, and playing a role in muscle function. It's unique among vitamins because the body can produce it when exposed to sunlight....

Vitamin D

Vitamin A is crucial for vision, immune function, and skin health. It helps with eyesight, especially in low light, and keeps skin and mucous membranes healthy. Vitamin A is in foods like carrots, sweet potatoes, and leafy greens. Animal sources include liver and dairy products. Too little can lead to vision problems and a weak immune system. Vitamin A also supports growth and reproduction....

Vitamin A

Vitamin B3, also known as niacin, is important for converting food into energy. It's key for the health of your skin, nerves, and digestive system. B3 is in meat, fish, poultry, and whole grains. Some people may need supplements, especially with certain medical conditions. A lack of B3 can lead to skin issues, tiredness, and confusion. B3 helps maintain cholesterol levels and supports overall health....

Vitamin B3

Holotranscobalamin (holoTC), also known as active vitamin B12, is a form of vitamin B12 that is bound to transcobalamin, a transport protein in the blood. This combination is biologically significant because it is the only form of vitamin B12 that can be taken up by cells via receptor-mediated endocytosis, making it readily available for cellular processes. Measurement of holotranscobalamin levels is considered a more direct marker of the recent vitamin B12 status in the body than the total vitamin B12 test, as it represents the fraction of vitamin B12 that is actually available for cellular uptake and immediate use....




Holotranscobalamin (B12)

25-hydroxy Vitamin D3 (25(OH)D3) is the primary circulating form of vitamin D in the human body and the most accurate marker for assessing vitamin D status. It is synthesized in the skin upon exposure to UVB radiation from sunlight and can also be obtained from dietary sources such as fatty fish, egg yolks, and fortified foods.

Once produced or ingested, vitamin D3 is converted in the liver to 25(OH)D3, which is the major storage form of vitamin D. This form is essential for maintaining calcium and phosphate balance, supporting bone health, and modulating immune, endocrine, and neuromuscular functions.

25-hydroxy Vitamin D3

25-hydroxy Vitamin D2 (25(OH)D2) is one of the two main forms of vitamin D measured in the blood, the other being 25-hydroxy Vitamin D3. While Vitamin D3 is typically produced in the skin through sunlight exposure and obtained from animal-based sources, Vitamin D2 is derived from plant-based sources and supplements.

25(OH)D2 is converted in the liver from ergocalciferol (Vitamin D2) and reflects the body's intake of this form of the vitamin. It plays a role in calcium and phosphate metabolism, immune function, and overall bone health. Although Vitamin D2 is less potent and has a shorter half-life than Vitamin D3, both forms contribute to total vitamin D status.

25-hydroxy Vitamin D2

Allergies

Amino Acids

Bacterias

Fatty Acids

Fertility Markers

Food Intolerances

Gut Markers

Health Markers

Heavy Metals

Hormones

Minerals

Neurotransmitters

Other

Parasites Worms

STIs

Toxic elements

Yeast Fungus

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Holotranscobalamin & Vitamin B12 | Key Insights | GetTested

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Holotranscobalamin (holoTC) is the active form of vitamin B12, crucial for cellular uptake. Learn its role and how it serves as a marker of vitamin B12 status.

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Blood Tests

Persistent fatigue and thyroid issues are often linked to B12 levels. While a standard B12 test might show normal total levels, it is the active form of B12, which makes up only 10-30% of the total, that plays a vital role in your health. GetTested&rsquo;s Vitamin B12 Test specifically measures this active form. For a more comprehensive health assessment, our Vitamin Test includes standard B12, folate, vitamins D and E, and CoQ10, providing a detailed nutrient profile for those looking to address fatigue.

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Individuals who are at risk of vitamin B12 deficiency, such as vegetarians, elderly people, and those with absorption impairments like pernicious anemia or gastrointestinal disorders, would benefit from testing their holotranscobalamin levels. It helps in early detection and management of deficiency.

Who would benefit from testing their holotranscobalamin levels?

Symptoms of low holotranscobalamin, indicating vitamin B12 deficiency, include fatigue, weakness, memory loss, neurological and psychiatric problems, and anemia. These symptoms result from the impaired production of DNA and red blood cells and neurological function.

What are symptoms of low holotranscobalamin?

Holotranscobalamin testing measures only the biologically active portion of vitamin B12 available for cellular uptake, providing a more accurate reflection of functional vitamin B12 status. In contrast, total vitamin B12 testing measures all forms of B12, including those that are not immediately available to cells, which can sometimes mask deficiencies.

How does holotranscobalamin differ from total vitamin B12 testing?

Low holotranscobalamin levels are primarily caused by dietary inadequacy, malabsorption syndromes, pernicious anemia, certain medications, and age-related decline in absorption. These factors lead to insufficient availability of biologically active vitamin B12.

Holotranscobalamin (B12)

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