Cis-aconitate is an intermediate in the Krebs cycle, a central metabolic pathway involved in cellular energy production. It is formed during the conversion of citrate to isocitrate, a reaction catalyzed by the enzyme aconitase. The Krebs cycle plays a vital role in oxidizing nutrients to produce ATP, the main energy source for cells, and also supplies key building blocks for the synthesis of amino acids, nucleotides, and fatty acids.
Testing cis-aconitate levels might benefit certain individuals:
Dysregulated cis-aconitate levels can be indicative of broader metabolic disturbances. While cis-aconitate itself may not directly cause specific symptoms, abnormalities in its levels can reflect or contribute to metabolic dysfunctions, which may manifest as various symptoms. These might include:
Regulating cis-aconitate levels in the body is primarily about ensuring the proper functioning of the Krebs cycle and overall metabolic health, as cis-aconitate is an intermediate in this crucial metabolic pathway. Some general strategies can support healthy metabolic function, which in turn can help maintain appropriate cis-aconitate levels:
Cis-aconitate levels in the body can be influenced by several factors, primarily related to metabolic health and cellular function. Key factors include: