Organic acids test UK
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Organic Acids Test

Test type
Lab Test

We offer two types of tests; Lab Tests and Rapid Tests. This product is under the category Lab Tests. See all our Lab Tests by following the link.

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Collection method
Urine

We offer several different options of testing methods. This test is done with Urine. See all tests done with Urine by following the link.

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€ 249,00

(12)

The Organic Acids Test from GetTested is a detailed assessment measuring 21 different markers of the body’s metabolic processes. This test is ideal for uncovering the root causes of chronic illnesses and is particularly beneficial for individuals experiencing fatigue, burnout, or low energy. It is an easy to use test and therefore also suitable for children.

For those seeking further insights into their biochemical balance, we recommend the Neurotransmitters Basic Test, which measures levels of serotonin, dopamine, adrenaline, noradrenaline, and the ratio between adrenaline and noradrenaline.

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About the Organic Acids Test

The Organic Acids Test measures a broad group of substances used in the body’s basic metabolic processes. When you analyse organic acids, you gain insight into how your body uses nutrients from food and converts them into energy (ATP). This process involves enzymes and their cofactors. If you lack these cofactors or if the enzymes are not working optimally, certain substances may accumulate. Measuring these substances’ concentrations can reveal potential vitamin and mineral deficiencies. Additionally, metabolic products of neurotransmitters in urine can indicate stress hormone imbalances, and dysbiosis markers may point to bacterial imbalances in the gut.

Indicators measured by the test

Items measured for Lipid metabolism

Adipate
Adipate, or adipic acid, is a component in lipid metabolism and a biomarker for certain metabolic dysfunctions, particularly those affecting fatty acid oxidation. This abnormal presence, often found in urine or blood tests, can help diagnose and monitor metabolic conditions.
Suberic acid
Suberic acid, also known as octanedioic acid, is a dicarboxylic acid that in a biological and physiological context, is primarily significant as a metabolic marker. Elevated levels of suberic acid in the body can indicate metabolic disorders, especially those related to fatty acid oxidation, such as medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency.
Ethyl malonate
Ethyl malonate, from a metabolic perspective, is significant as a biomarker for certain metabolic disorders. Elevated levels of ethyl malonate in the body, can indicate inherited metabolic disorders, such as ethylmalonic encephalopathy, or problems with fatty acid oxidation.

Carbohydrate metabolism

Lactate
Lactate, commonly known as lactic acid, is a byproduct of anaerobic metabolism, produced when the body breaks down glucose for energy without adequate oxygen, typically during intense exercise. It's associated with muscle fatigue and the "burn" sensation during strenuous activity. Lactate also plays a role in the Cori cycle, where it's converted back to glucose in the liver.
Pyruvate
Pyruvate is a key compound in cellular metabolism, formed as the end product of glycolysis when glucose is broken down. In the presence of oxygen, it contributes to energy production by entering the citric acid cycle. Under low oxygen conditions, such as during intense exercise, pyruvate is converted into lactate, allowing continued ATP (energy) production. Pyruvate also plays a role in gluconeogenesis, the process of generating glucose from non-carbohydrate sources, and is a precursor for amino acid synthesis.
Beta-hydroxybutyrate
Beta-hydroxybutyrate (BHB) is a ketone body produced by the liver from fatty acids during periods of low food intake, fasting, intense exercise, or a low-carbohydrate diet. It serves as an alternative energy source, especially for the brain, when glucose is scarce. BHB is a key indicator of ketosis, a metabolic state achieved through ketogenic diets or fasting.

Organic acids in the citric acid cycle

Alpha-ketoglutarate
Alpha-ketoglutarate (AKG) is a key compound in the Krebs cycle, an essential metabolic pathway for energy production in cells. It plays a crucial role in converting nutrients into energy, amino acid metabolism, and nitrogen transport. Additionally, Alpha-ketoglutarate is involved in various cellular processes, including signaling and regulation.
Succinate
Succinate is a key intermediate in the Krebs cycle, essential for energy production in cells. It helps convert nutrients into ATP, the cell's main energy source. Beyond its role in the Krebs cycle, succinate serves as a metabolic link in processes like amino acid and fatty acid synthesis. It also acts as a signaling molecule, influencing inflammation and response to low oxygen conditions.
Cis-aconitate
Cis-aconitate is an intermediate in the Krebs cycle, a key metabolic pathway involved in energy production in cells. It forms during the conversion of citrate to isocitrate, facilitated by the enzyme aconitase. This cycle is crucial for oxidizing nutrients to generate ATP, the primary energy currency of the cell. Additionally, the Krebs cycle, including the cis-aconitate step, provides important precursors for biosynthetic pathways like amino acid, nucleotide, and fatty acid synthesis.
Hydroxymethylglutarate
Hydroxymethylglutarate (HMG), particularly in its form as β-hydroxy β-methylglutaryl-CoA (HMG-CoA), is crucial in human physiology, serving two primary functions. First, it is a key intermediate in cholesterol synthesis, essential for the formation of cell membranes, steroid hormones, and bile acids. Second, in the liver, HMG-CoA is involved in the production of ketone bodies during periods of fasting, carbohydrate-restricted diets, or intense exercise, providing an alternative energy source when glucose is low.
Isocitrate
Isocitrate is a crucial compound in the Krebs cycle, a key metabolic pathway for energy production in cells. It is formed from citrate and then converted to α-ketoglutarate, a process that generates NADH for ATP production. Isocitrate plays a role in linking various metabolic processes, including the synthesis of amino acids, nucleotides, and fatty acids.
Malate
Malate, or malic acid, is a crucial compound in cellular metabolism, particularly in the Krebs cycle, which occurs in the mitochondria. It plays a key role in energy production by being converted to oxaloacetate, a process that generates NADH, subsequently used to produce ATP, the cell's energy currency.
Citrate
Citrate is a key component in the citric acid cycle, crucial for energy production in aerobic organisms. It helps in breaking down carbohydrates, fats, and proteins to generate ATP (energy). Citrate also aids in regulating the body's acid-base balance and plays a role in preventing kidney stones by binding with calcium.

Organic acids of vitamin metabolism

Xanthurenate
Xanthurenate is a metabolite produced from the breakdown of the amino acid tryptophan via the kynurenine pathway. Elevated levels of xanthurenate can indicate a deficiency in vitamin B6 (pyridoxine), as this vitamin is a necessary cofactor in the pathway.
Methylmalonic acid (MMA)
Methylmalonic acid (MMA) is a substance produced in the body during the metabolism of certain fats and proteins. It is a byproduct of the breakdown of an amino acid called methionine, and its levels are influenced by the amount of vitamin B12 in the body. MMA is particularly significant because elevated levels can be an indicator of vitamin B12 deficiency.

Degradation of neurotransmitters

Vanillylmandelic acid
Vanillylmandelic acid (VMA) is a metabolite resulting from the breakdown of catecholamines like adrenaline, noradrenaline, and dopamine. It serves as a clinical marker for assessing catecholamine activity. VMA levels are typically measured in urine and can be influenced by certain foods and medications.
Homovanillic acid
Homovanillic acid (HVA) is a metabolite resulting from the breakdown of dopamine, a key neurotransmitter. It serves as an important marker for assessing dopamine activity in the body. Changes in HVA levels can indicate alterations in dopamine function, and they are also used to monitor the effectiveness of treatments that affect dopamine metabolism.
5-Hydroxyindoleacetate
5-Hydroxyindoleacetate (5-HIAA) is the primary metabolite of serotonin, a key neurotransmitter. It is used clinically as a diagnostic marker, particularly in the detection and monitoring of carcinoid tumors, which can overproduce serotonin. Urinary 5-HIAA can also be used as a approximate marker for serotonin levels in the body.
Kynurenic acid
Kynurenic acid is a metabolite produced in the kynurenine pathway, which is involved in the metabolism of the amino acid tryptophan. It is known for its role in the nervous system, where it acts as a neuroprotective agent. It's significant in neurological and psychiatric research, as imbalances are linked to conditions like schizophrenia and depression.

Dysbiosis markers

D-arabinitol
D-arabinitol is a sugar alcohol used as a biomarker for diagnosing and monitoring Candida infections, particularly in immunocompromised patients. Elevated levels of D-arabinitol can indicate an overgrowth of Candida, often associated with systemic candidiasis. Its measurement can provide a quicker and non-invasive diagnostic alternative compared to traditional culture methods.
Citramalate
Citramalate, or citramalic acid, is a metabolic byproduct and a urinary marker that can indicate bacterial dysbiosis or overgrowth. Its presence can also be indicative of potential metabolic disturbances.

The health benefits of Organic Acids 

Organic Acids have various health benefits such as:

  • Maintaining the cellular integrity of the gut lining
  • Improving digestion
  • Reducing inflammation
  • Improving the absorption of proteins, amino acids and minerals.
  • Protecting the immune system by providing energy and regulating metabolism

It is important to have a decent amount of Organic Acids in the body, not too little but also not too much, as too many Organic Acids can cause side effects like nausea, vomiting or diarrhoea. Consult with your healthcare provider about whether you should take supplements or make dietary changes after receiving your Organic Acid test results.

Understanding Your Health with our test

GetTested is dedicated to offering accessible and accurate health diagnostics. We designed our Organic Acids test to empower you with knowledge about your health status. The urine organic acids test is a convenient test, because you can simply collect a urine sample from the comfort of your home using our user-friendly test kit. 

Urine testing is highly effective, because organic acids are found in high amounts in urine. The special lab techniques separate the acids out to analyse them. If you may have a metabolic imbalance, it may show up as abnormal organic acids in your test results.

How to perform the Organic Acids Test

You perform the Organic Acids Test at home by collecting your second morning urine. After collecting the sample, you send it to a lab for analysis. You will receive your digital test results once the lab completes the analysis. Since the Organic Acid Test uses a urine sample, it is suitable for children as well.

FAQ

How is the Organic acids test carried out?

Our Organic acids test is a home test kit. After ordering, we will send you a kit with everything you need to collect the urine sample. Then, simply return your sample to us in the pre-paid envelope.

When should I take the test?

It should be collected from the second morning urine, i.e. the second time you urinate after getting up in the morning. Collect urine from halfway through urination. Do not use the first or last urine but in the middle of the urination. Avoid drinking coffee before the test.

How quickly will I receive my results?

Once we receive your sample, average response time is 10-15 business days to receive results.

What does urine organic acids test for?

The urine organic acids test measures organic acids in urine. These organic acids consist of a broad group of substances that are used in the body’s basic metabolic processes.

What does organic acids test show?

An organic acids test shows how your body processes nutrients and it can detect potential vitamin and mineral deficiencies. By doing so, it helps assess the functional need for dietary changes or special treatments. Essentially, an organic test provides a detailed nutritional and metabolic image of a person’s health.

Example Report

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Example of Organic Acids Test

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  • Tara Singh
    Revelatory insights. Comprehensive report. Improved my health strategy immensely.
  • Sofia
    informative and insightful

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