VPS37B
VPS37B, a member of the vacuolar protein sorting (VPS) family, is a crucial component of the endosomal sorting complex required for transport (ESCRT) machinery. Located predominantly within the cytoplasm of cells, VPS37B plays a pivotal role in regulating intracellular membrane trafficking and protein sorting processes. One of the key functions of VPS37B is its involvement in the formation and function of multivesicular bodies (MVBs), specialized endosomal compartments responsible for sorting ubiquitinated membrane proteins destined for degradation in lysosomes. Within the ESCRT machinery, VPS37B interacts with other ESCRT components to facilitate the sequestration of cargo into intraluminal vesicles within MVBs, a process...
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