VPS37B is a gene that encodes a protein involved in the endosomal sorting complex required for transport (ESCRT) machinery. It plays a key role in intracellular membrane trafficking and protein sorting, particularly in the formation of multivesicular bodies (MVBs). By helping to direct ubiquitinated proteins toward lysosomal degradation, VPS37B contributes to maintaining cellular homeostasis and regulating signal transduction pathways.