TENM3

TENM3 (Teneurin-3): TENM3, a member of the teneurin family of transmembrane proteins, serves as a multifunctional regulator in various aspects of neural development and synaptic connectivity. This protein's intricate role encompasses guidance cues in axonal pathfinding, dendritic arborization, and synaptic organization, contributing significantly to the establishment and refinement of neural circuits during development. Beyond its developmental functions, TENM3 also participates in synaptic maintenance and plasticity in the adult nervous system, influencing processes such as synaptic pruning and neurotransmitter release. Dysregulation of TENM3 has been associated with neurological disorders, including autism spectrum disorders and schizophrenia, underscoring its importance in maintaining proper neural circuitry and cognitive function. Understanding the molecular mechanisms underlying TENM3's actions holds promise for elucidating the pathophysiology of neurodevelopmental disorders and may offer avenues for therapeutic interventions targeting synaptic connectivity and plasticity.