SH2B3
SH2B3 (SH2B Adaptor Protein 3): SH2B3, also known as LNK, is an adaptor protein that negatively regulates cytokine signaling in hematopoietic cells. It plays a crucial role in maintaining hematopoietic stem cell homeostasis and regulating immune responses. SH2B3 mutations are associated with a variety of hematologic disorders, including myeloproliferative neoplasms and autoimmune diseases, underscoring its importance in blood cell development and immune regulation....
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