PLTP

PLTP (Phospholipid Transfer Protein): PLTP, also known as phospholipid transfer protein, is a key player in lipid metabolism and lipid transport processes within the body. It facilitates the transfer of phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, between different lipoprotein particles, thereby regulating their composition and metabolism. PLTP plays a crucial role in the maintenance of plasma lipoprotein homeostasis, influencing the size, composition, and functionality of various lipoprotein fractions, including high-density lipoproteins (HDL) and low-density lipoproteins (LDL). Its activity is essential for processes like reverse cholesterol transport, which removes excess cholesterol from peripheral tissues and delivers it to the liver for excretion. Dysregulation of PLTP has been implicated in metabolic disorders such as dyslipidemia, atherosclerosis, and insulin resistance, highlighting its significance in cardiovascular health and lipid-related diseases. Understanding the molecular mechanisms underlying PLTP function presents opportunities for the development of therapeutic interventions targeting lipid metabolism and cardiovascular risk factors.