ORMDO3

ORMDO3 (Oligoribonuclease, mitochondrial): Much like MMP15's role in regulating the extracellular matrix (ECM) and tissue integrity, ORMDO3 plays a critical role in maintaining cellular homeostasis within the mitochondria, the powerhouse of the cell. ORMDO3 is an essential enzyme involved in RNA degradation, specifically targeting short RNA fragments within the mitochondria. By facilitating the turnover of mitochondrial RNA molecules, ORMDO3 contributes to the regulation of mitochondrial gene expression and ensures proper mitochondrial function. Dysfunction or dysregulation of ORMDO3 activity can lead to mitochondrial RNA accumulation, impairing mitochondrial function and cellular health. Consequently, abnormalities in ORMDO3 have been associated with various mitochondrial disorders, neurodegenerative diseases, and metabolic syndromes. Understanding the precise mechanisms underlying ORMDO3-mediated mitochondrial RNA turnover may offer insights into mitochondrial dysfunction-related pathologies and potential therapeutic strategies for these disorders.